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Patients will start on a twice weekly dose for a month at a cost of $4,720 to $6,785, followed by weekly or alternate weekly dosing at a cost of $2,360 to $3,540 per month. Mar 19 · approved in us for use in combination with oral antidepressants in patients who have tried at least two antidepressants without success. Spravato is indicated for treatment resistant depression (major depressive disorder in adults who have not responded adequately to at least two different antidepressants of adequate dose and duration to treat the current moderate to severe depressive episode). But it wasn’t until recently that esketamine, a more potent version of ketamine.